Swi6/HP1 Recruits a JmjC Domain Protein to Facilitate Transcription of Heterochromatic Repeats
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چکیده
منابع مشابه
Small RNAs correspond to centromere heterochromatic repeats.
Small interfering RNAs (siRNAs) and microRNAs (miRNAs) are two types of 22– nucleotide (nt) noncoding RNAs that play important roles as regulators of gene expression in eukaryotes (1). siRNAs derive from the successive cleavage of long double-stranded RNA (dsRNA). They direct the destruction of corresponding mRNA targets during RNA interference in animals and probably during other RNA-silencing...
متن کاملA novel jmjC domain protein modulates heterochromatization in fission yeast.
The heterochromatin domain at the mat locus of Schizosaccharomyces pombe is bounded by the IR-L and IR-R barriers. A genetic screen for mutations that promote silencing beyond IR-L revealed a novel gene named epe1, encoding a conserved nuclear protein with a jmjC domain. Disruption of epe1 promotes continuous spreading of heterochromatin-associated histone modifications and Swi6 binding to chro...
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Many proteins, especially in eukaryotes, contain tandem repeats of several domains from the same family. These repeats have a variety of binding properties and are involved in protein-protein interactions as well as binding to other ligands such as DNA and RNA. The rapid expansion of protein domain repeats is assumed to have evolved through internal tandem duplications. However, the exact mecha...
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MBD4 is the only methyl-CpG binding protein that possesses a C-terminal glycosylase domain. It has been associated with a number of nuclear pathways including DNA repair, DNA damage response, the initiation of apoptosis, transcriptional repression, and DNA demethylation. However, the precise contribution of MBD4 to these processes in development and relevant diseases remains elusive. We identif...
متن کاملKDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state.
Heterochromatin plays an essential role in the preservation of epigenetic information, the transcriptional repression of repetitive DNA elements and inactive genes, and the proper segregation of chromosomes during mitosis. Here we identify KDM2A, a JmjC-domain containing histone demethylase, as a heterochromatin-associated and HP1-interacting protein that promotes HP1 localization to chromatin....
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2006
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2006.05.010